FOLDING PROTEINS

摘要

Nucleic acid encoding subunits of a polypeptide folding complex containing TCP-1 is useful in expression of the subunits for assembly of the complex in vitro or in vivo. The complex promotes folding of polypeptides, such as tubulin, e.g. following recombinant expression. The sequences share a high degree of homology but the C-terminii are sufficiently different to enable peptides with sequences derived therefrom to be used in obtaining antibodies specific for the various subunits, i.e. able to distinguish between them. The antibodies may be used in analysis and design of complexes able to fold different polypeptides.