| 摘要 |
<p>The present invention discloses three human DNA repair proteins and DNA (RNA) encoding such proteins and a procedure for producing such proteins by recombinant techniques. One of the human DNA repair proteins, hMLH1, has been mapped to chromosome 3 while hMLH2 has been mapped to chromosome 2 and hMLH3 has been mapped to chromosome 7. The invention provides methods to diagnose alterations in the hMLH1, hMLH2 and hMLH3 genes.</p> |
