| 摘要 |
A biocompatible, bioresorbable, non-toxic adhesive compsn. (I) for surgical use, esp. for bonding biological tissues to each other or to implanted biomaterial, comprises a reactive acidic soln. of collagen or gelatin which has been modified by oxidative cleavage and is non-crosslinked but potentially crosslinkable. Also claimed are: (a) powdered collagen or gelatin, modified by oxidative cleavage, which is non-crosslinked, potentially crosslinkable and soluble at acidic pH; (b) a conc. reactive acidic soln. of the modified collagen or gelatin, for forming an adhesive soln.; (c) an adhesive kit consisting of (I) and a neutralising soln. (II) which can be mixed immediately before use; (d) a method of applying (I) to biological tissues and/or biomaterial by adjusting (I) to a fluidity suitable for distribution on the substrate, mixing (I) with (II) immediately before use to give pH 6-10, applying the fluid mixt. (before crosslinking) to the substrate and allowing the mixt. to polymerise by crosslinking at human body temp.; and (e) the use of (I) for the prepn. of a bioresorbable, biocompatible, non-toxic adhesive material, consisting of collagen or gelatin which is completely and homogeneously crosslinked in bulk. |
