| 摘要 |
The invention relates to a novel process for the preparation of ergothioneine. The process for the chemical synthesis of the different optical forms of ergothioneine essentially comprises steps which consist in preparing or using an N alpha ,N alpha -dimethylated histidine ester salt (optically active if necessary), treating this compound with an alkyl, alkenyl or aryl halogenothionoformate in the presence of a base, protecting the sulfur-containing substituent in the compound obtained, converting this protected compound to a compound of the trimethylammonium type and freeing the desired ergothioneine by saponification or acid hydrolysis, as appropriate. This process affords a better yield and ensures an excellent optical purity.
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