| 摘要 |
PCT No. PCT/GB95/00019 Sec. 371 Date Jun. 20, 1996 Sec. 102(e) Date Jun. 20, 1996 PCT Filed Jan. 6, 1995 PCT Pub. No. WO95/18808 PCT Pub. Date Jul. 13, 1995Linked polyamine cyclic compounds of general formula V-R-A-R'-W where V and W are independently cyclic polyamine moieties having from 9 to 32 ring members and 3 to 8 amine nitrogens and having either one or more aromatic rings fused thereto or a heteroatom other than nitrogen incorporated in the ring, A is an aliphatic or aromatic moiety and R and R' are each a linking chain, possess improved partition coefficients at biologically relevant pH compared to known compounds, and possess high anti-HIV activity. |
