| 摘要 |
PURPOSE:To obtain a highly sensitive diagnosing medicine by bonding a fusion protein prepared by bonding a carrier protein to a hepatitis C-virus (HCV) antigen protein to hydrophilic particles. CONSTITUTION:A diagnosing medicine for HCV infectious disease is obtained by bonding a fusion protein obtained by bonding a carrier protein to an HCV antigen protein to hydrophilic particles. The antigen protein is a structural or nonstructural protein. The structural protein includes envelope proteins, core proteins, etc., and the nonstructural protein includes NS1-NS5 proteins, polypeptide composed of 8 or more, preferably, 40 or more amino acids containing at least one epitope of these proteins. When a plurality of proteins is used in a combined way as the antigen protein, no limitation exists against the coupling order of the proteins. The fusion protein is prepared by coupling a carrier protein to the N-terminal side of the antigen protein. |
