| 摘要 |
The present invention provides new and structurally diverse compositions comprising compounds of general formula (I), wherein A is N-G or P-G; B is N or P; C is N or P; D is N-G or P-G; E is N-G, P-G or C(R6)-[CH(R7)]q-X; G is -[CH(R8)]i-X; X is -CO2H, -OPO3H2, -PO3H2, -SO3H, -SH, -OH, or -CONHOH; R1, R2, R3, R4, R5, R6, R7 and R8 can be the same or different and are hydrogen, C1-C8 alkyl, or C6-C10 aryl, optionally substituted by one or more hydroxy, C1-C8 alkyl, C-1<-C>8< hydroxyalkyl, C>1<-C>8< alkoxy, C>6<-C>10< aryl, C>6<-C>10< hydroxyaryl, C>6<-C>10< aryloxy, -CO>2<R>7<, -CONR>10<R>11<, or -NR>10<R>11< groups; R>9<, R>10<, and R>11< may be the same or different and are selected from the group consisting of hydrogen, C>1<-C>8< alkyl, C>1<-C>8< hydroxyalkyl and C>1<-C>8< alkoxyalkyl; R>10< and R>11< may form a 5 or 6 membered carbocyclic ring optionally containing singularly or in combination nitrogen, oxygen or sulfur; i, j, k, l, m, n and q may be the same or different and are zero to about 5. Methods for imaging using compositions of the invention are also provided. |
