发明名称 |
MOLECULAR DECOYANTS AND METHODS OF USE THEREOF |
摘要 |
Molecular decoyants are chemical structures which functionally resemble an endogenous receptor. They may be used for the treatment of humans or other animals which have been subjected to a foreign agent which exerts an undesired effect only after first binding to that endogenous receptor. A decoyant is a fraction of an endogenous receptor which retains the essential elements of the binding site of the receptor for the foreign agent or is a synthetic or biosynthetic derivative thereof. The .alpha.-184-200 amino acid sequence of Torpedo californica acetylcholine receptor is an example of a decoyant which protects against curarimimetic neurotoxins. Another example is the fraction of the CD4 receptor which retains the essential elements of the receptor for protection against HIV.
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申请公布号 |
CA1336489(C) |
申请公布日期 |
1995.08.01 |
申请号 |
CA19880576111 |
申请日期 |
1988.08.30 |
申请人 |
YEDA RESEARCH AND DEVELOPMENT COMPANY, LTD. |
发明人 |
GERSHONI, JONATHAN M. |
分类号 |
A61K38/00;A61K47/48;C07K7/08;C07K14/705;C07K14/73;(IPC1-7):A61K37/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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