Novel controlled release formulations of tetracycline compounds.

摘要

Pharmaceutical compositions comprising spherical granules including thereon or therein a 7- or 9-alkylamino-6-deoxy-6-demethyltetracycline or an acid-addition salt thereof blended with at least one exccipient are adapted to control the rate of drug release in the stomach and in the intestine in order not to produce nausea or dizziness upon oral administration during antibacterial therapy.