发明名称 |
Stable solutions of rebeccamycin analog and preparation thereof. |
摘要 |
<p>Stable solutions of rebeccamycin analog consist essentially of (a) water, (b) 8-N-(diethylaminoethyl)rebeccamycin in an effective dosage amount, and (c) pharmaceutically acceptable acid such that the presence of a molar equivalence thereof would solubilize (b), said acid being present in excess of said molar equivalence to provide a stabilizing pH ranging from 3 to 4, preferably from 3.0 to 3.6. A preferred solution contains 10 mg/ml of the free base and tartaric acid in equimolar amount with the free base to provide a pH of 3.5. Preferably, the solution is prepared by forming a suspension of 8-N-(diethylaminoethyl)rebeccamycin in water and adding acid to provide a pH ranging from 3 to 4.</p> |
申请公布号 |
GR3015714(T3) |
申请公布日期 |
1995.07.31 |
申请号 |
GR19950400845T |
申请日期 |
1995.04.07 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
VENKATARAM, UBRANI V.;FRANCHINI, MIRIAM K.;BOGARDUS, JOSEPH B. |
分类号 |
C07H19/23;A61K9/00;A61K9/08;A61K31/4184;A61K31/70;A61K31/7004;A61K31/7042;A61K31/7052;A61K47/02;A61K47/04;A61K47/12;A61K47/26;A61P35/00;C07C55/10;C07C59/08;C07C59/245;C07C59/255;C07C59/265;C07H17/02;C07H19/044;(IPC1-7):C07H19/044;A61K31/71 |
主分类号 |
C07H19/23 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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