发明名称 |
SUBSTITUTED CARBOXYLIC ACID DSE DERIVATES, PREPARATION PROCESSES THEREFOR AND PHARMACEUTIC COMPOSITIONS THAT CONTAIN THEM THEREOF |
摘要 |
The invention relates to compounds of the formula Q and n are as described herein. Their pharmaceutically acceptable salts, and when appropriate, enantiomers, racemates, diastereomers or mixtures thereof or geometric isomer or mixtures thereof, and pharmaceutically acceptable salts thereof. The compounds of formula I inhibit enzyme carnitine acyltransferase 1 (CAT-1) and are therefore useful in the prevention of injury to ischemic tissue, and can limit infarct size, improve cardiac function and prevent arrhythmias during and following a myocardial infarction. |
申请公布号 |
RO109938(B1) |
申请公布日期 |
1995.07.28 |
申请号 |
RO19920200622 |
申请日期 |
1992.05.08 |
申请人 |
F HOFFMANN LA ROCHE AG, BASEL |
发明人 |
ROBERT WILLIAM GUTHRIE;GUY PHILLIP HEATHERS;ALAN JOHN HIGGINS;DAVID FRANCIS KACHENSKY;RICHARD WIGHTMAN KIERSTEAD;RONALD ANDREW LEMAHIEU;JOHN GUILFOYLE MULLIN JR;JEFFERSON WRIGH TILLEY |
分类号 |
A61K31/192;A61K31/38;A61K31/44;A61P9/10;C07C45/00;C07C45/46;C07C45/56;C07C45/71;C07C47/55;C07C49/825;C07C49/84;C07C59/68;C07C59/90;C07C65/40;C07C69/00;C07C69/007;C07C69/734;C07C69/736;C07C69/738;C07C205/37;C07C205/56;C07C219/14;C07C229/36;C07C229/42;C07C233/54;C07C233/69;C07C233/87;C07C235/22;C07C235/24;C07C235/34;C07C235/78;C07C235/84;C07C251/48;C07C271/22;C07C281/14;C07C309/65;C07C311/29;C07C317/44;C07C323/12;C07C323/18;C07C323/62;C07D207/34;C07D213/54;C07D213/60;C07D215/14;C07D215/20;C07D215/22;C07D215/233;C07D217/02;C07D217/04;C07D221/12;C07D233/54;C07D263/12;C07D275/00;C07D295/185;C07D307/54;C07D307/56;C07D307/80;C07D309/12;C07D317/00;C07D317/24;C07D333/24;C07D333/26;C07D333/32;C07D493/14;C07F7/18 |
主分类号 |
A61K31/192 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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