IMPROVED PROCESS FOR SYNTHESIZING CARBAPENEM INTERMEDIATES
摘要
This invention relates to the synthesis of a bicyclic ketoester compound of formula (1) obtained by cyclizing a diazo compound of formula (2) in the presence of a rhodium catalyst. By adding an effective amount of a Lewis acid to the cyclization reaction, the reaction selectively produces the 1-beta methyl isomer, and epimerization of the 1-beta methyl compound to the 1-alpha isomer is minimized.
申请公布号
WO9519979(A1)
申请公布日期
1995.07.27
申请号
WO1995US00855
申请日期
1995.01.20
申请人
MERCK & CO., INC.;LIU, THOMAS, MENG-HAN;LYNCH, JOSEPH, E.;VOLANTE, RALPH, P.
发明人
LIU, THOMAS, MENG-HAN;LYNCH, JOSEPH, E.;VOLANTE, RALPH, P.