| 摘要 |
<p>A pyrrolopyridazine derivative represented by general formula (I) and a pharmacologically acceptable salt thereof, wherein R1 represents C¿2?-C6 alkenyl, halogenated C2-C6 alkenyl, (C6-C10 aryl)-substituted C2-C6 alkenyl, C2-C6 alkynyl, C3-C7 cycloalkyl, (C3-C7 cycloalkyl)-substituted C1-C6 alkyl, (C5-C7 cycloalkenyl)-substituted C1-C6 alkyl or halogenated C1-C6 alkyl; R?2 and R3¿ represent each independently hydrogen, C¿1?-C6 alkyl or C6-C10 aryl; R?4¿ represents hydrogen or C¿1?-C6 alkyl; R?5¿ represents C¿6?-C10 aryl or five- to ten-membered heteroaryl wherein heteroatom(s) is(are) selected from among nitrogen, oxygen and sulfur atoms; A represents C1-C3 alkylene; X represents imino, oxygen, sulfur or methylene; m represents 0 or 1; and n represents 0 or 1. The derivative has excellent effects of suppressing gastric secretion and protecting gastric mucosa and an excellent antibacterial activity against Helicobacter pylori, thus being useful as a preventive or remedy for ulcerative diseases and the like.</p> |
