| 摘要 |
<p>A pyridazinone derivative represented by general formula (I) and an antithrombocytic agent containing the same, wherein R represents hydrogen or C1-C4 alkyl; X represents hydrogen, chlorine or bromine; An represents pyridyl or phenyl substituted by OR1 (R1 representing hydrogen or C¿1?-C4 alkyl) and A (representing hydrogen, halogen, C1-C4 alkyl or OR?2 (R2¿ representing hydrogen or C¿1?-C4 alkyl)); Y represents C1-C8 alkylene wherein one carbon atom on the straight chain is substituted by one OR?1¿ group (R1 being as defined as above); and Z?1 and Z2¿ represent each independently hydrogen, halogen, C¿1?-C4 alkyl or OR?1 (R1¿ being as defined above). This compound has a potent antithrombocytic activity and an excellent safety and is used as the active ingredient of a preventive or remedy for various thrombotic diseases.</p> |
