| 摘要 |
Derivatives of benzocycloalkenyldihydroxyalkanoic acids, inhibitors of HMG CoA reductase, antagonists of thromoboxane A2 receptors and antifungals, denoted by the formula I <IMAGE> 1 in which X=CH2, O or S; R1 and R2, identical or different, =H, C1-3 alkyl or together from a -(CH2)n- chain (n=4,5) optionally substituted symmetrically by one or two C1-3 alkyl radicals. R3 and R4, identical or different, =H, CF3, halogen (Cl, F, Br), C1-5 N,N-dialkylamino, C1-4 alkyl, C1-5-alkoxy, C1-3 alkylthio, or phenyl optionally substituted by at most two substitutents which may be identical or different and may denote C1-3 alkyl or C1-3 alkoxy radicals or halogens (F, Cl), it being understood that when one of R3 and R4 denotes the radicals: CF3, N,N-dialkylamino, C6H5 or substituted phenyl, it is present at the vertices 3', 4'or 5' according to formula 1 and the other denotes a hydrogen atom. R5 and R6, (which may be identical or different)=H, halogen (F, Cl, Br), CF3, C1-3 alkyl, C1-3 alkoxy, C6H5, optionally substituted by at most two substitutents which may be identical or different and may denote radicals: C1-3 alkyl or C1-3 alkoxy or halogen atoms (F, Cl), on condition that when one of R5 and R6=CF3, C6H5 or substituted phenyl, it is present at the vertex 6 or 7 and the other denotes a hydrogen atom. The substitutents R3 and R4 or R5 and R6 may also together form, on condition of being at two contiguous vertices, diradicals of formulae: -CH=CH-CH=CH-, -(CH2)m- and -O(CH2)pO-, in which m=3 or 4, p=1 or 2, it being understood that when R3 and R4 or R5 and R6 form the chain sequence -O(CH2)pO-, the latter is linked to the vertices 3' and 4' or 4' and 5' or 6 and 7 according to the formula 1. R7 and R8=H or, together with the existing C-C bond, form a double bond of trans geometry; R9 and R10=H or together form a C1-3 dialkylmethylene residue. In the form of free acids, salts, esters, amides or delta -lactones. Hypocholesterolaemiant, antithrombotic and antifungal medications containing them.
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