发明名称 |
Monoclonal antibodies against human Tumor Necrosis Factor alpha |
摘要 |
A monoclonal antibody is provided which is able to neutralize both human TNF alpha and TNF beta , or a binding fragment thereof. A stable hybridoma cell line and progeny thereof are also provided which secrete such a monoclonal antibody. The monoclonal antibody or a fragment thereof may be used to detect the content of human TNF in a sample of body fluid.
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申请公布号 |
US5436154(A) |
申请公布日期 |
1995.07.25 |
申请号 |
US19910806401 |
申请日期 |
1991.12.13 |
申请人 |
FARMITALIA CARLO ERBA S.R.L. |
发明人 |
BARBANTI, ELENA;GHISLIERI, MARTA;MARCUCCI, FABRIZIO;TRIZIO, DOMENICO |
分类号 |
A61K39/395;A61K38/00;A61P29/00;A61P37/06;C07K14/52;C07K14/525;C07K14/705;C07K14/715;C07K16/00;C07K16/24;C12N5/10;C12N5/16;C12N5/18;C12N5/20;C12N15/02;C12N15/06;C12P21/08;C12R1/91;(IPC1-7):A61K39/395;C12N5/12 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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