Sustained release suppositories and a process for preparation

摘要

A sustained release suppository comprising in a usual suppository base a) a water-soluble therapeutically active substance, the average particle size of which is smaller than 20 mu m, b) a physiologically acceptable organic substance which is swellable in contact with water, and c) hydrophobic silicium dioxide. The suppository base is usually a fat having a melting range of from 29 DEG to 38 DEG C. As ingredient b) cellulose derivatives such as hydroxypropylmethylcellulose may be used, in a quantity of from 5 to 40% by weight, preferably 9 to 15% by weight. Ingredient c) is preferably used in a quantity of from 3 to 6% by weight. Also a process for manufacturing the suppositories is described.