MOENOEMYCIN DECOMPOSITION PRODUCT HAVING HYDROXYLATED OR OXIDIZED LIPID SIDE CHAIN, MOENOEMYCIN HOMOLOGUE, PRODUCTION OF THESE COMPOUNDS AND USE OF THESE COMPOUNDS

摘要

The invention relates to MA of the formula I in which R<1>, R<2>, R<4> and R<5> independently of one another are a hydroxyl group or hydrogen and R<3> is hydrogen, where the bond between the C atom carrying the substituent R<4> and the C atom carrying the substituent R<5> is a single bond, or R<1> and R<2> independently of one another are a hydroxyll group or hydrogen and R<3> is hydrogen, where the bond between the C atom carrying the substituent R<4> and the C atom carrying the substituent R<5> is a double bond, or R<1>, R<2> and R<5> independently of one another are a hydroxyl group or hydrogen and R<3> and R<4> together are an oxo group. MA is hydroxylated or oxidised in the lateral lipid chain by microorganisms of the order Cryptococcus and in this form is a starting compound for the preparation of moenomycin analogues which can be employed as medicaments. The moenomycin analogues have the following chemical structure: in which R<1> to R<5> have the abovementioned meanings.h