| 摘要 |
The present invention relates to 3-aryl-oxirane derivatives of the formula <IMAGE> wherein Ar is 4'-quinoline or 5'-quinoline; each of R and R1 independently is hydrogen or C1-C6 alkoxy; one of X and Y is hydrogen, cyano, -COOR2 or -CONR3R4, and the other of X and Y is cyano, -COOR2 or -CONR3R4, wherein R2 is C1-C6 alkyl and each of R3 and R4 independently is hydrogen or C1-C6 alkyl, and pharmaceutically acceptable salts thereof, which are useful in therapy as tyrosine kinase inhibitors, in particular as anti-proliferative agents, typically as anti-cancer agents, in the treatment of psoriasis and in inhibiting the development of atheromatous plaque.
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