发明名称 |
PROCESS FOR MAKING XANTHENE OR CUBANE BASED COMPOUNDS, AND PROTEASE INHIBITORS |
摘要 |
Methods for forming combinatorial libraries and the libraries produced thereby are provided. According to a preferred aspect of the invention, a plurality of core molecules, the core molecule being a xanthene or cubane derivative, are reacted with a plurality of different tool molecules to form a library of molecules having non-naturally occurring molecular diversity. The libraries are useful for identifying lead compounds which modulate the functional activity of a biological molecule. Protease inhibitors that have been isolated from the libraries also are disclosed.
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申请公布号 |
WO9519359(A1) |
申请公布日期 |
1995.07.20 |
申请号 |
WO1995US00344 |
申请日期 |
1995.01.11 |
申请人 |
MASSACHUSETTS INSTITUTE OF TECHNOLOGY |
发明人 |
REBEK, JULIUS, JR.;CARELL, THOMAS;WINTNER, EDWARD, A. |
分类号 |
C07B61/00;C07D311/82;C07D405/06;(IPC1-7):C07D405/14;A61K31/35;C07C61/125;A61K31/185;A61K31/40 |
主分类号 |
C07B61/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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