发明名称 |
BIOLOGICAL TARGETING AGENTS |
摘要 |
A conjugate comprises a linear or cyclic synthetic peptide of 3-50 amino acids linked via one of its carboxyl groups and optionally via a linking group, to a polydentate metal chelating group, with the result that endo- or exo-peptidase metabolism of the peptide is substantially inhibited, with the provisos that: a) the peptide chain contains a biological targeting sequence which is biologically active; b) when the spacer is absent the metal chelating group does not comprise solely peptide moieties; c) the metal chelating group does not contain thiol donors. A complex of the conjugate with a metal atom chelated by the metal chelating group is useful in medicine.
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申请公布号 |
CA2179990(A1) |
申请公布日期 |
1995.07.20 |
申请号 |
CA19952179990 |
申请日期 |
1995.01.11 |
申请人 |
AMERSHAM INTERNATIONAL PLC |
发明人 |
BOWER, GARY ROBERT;FORSTER, ALAN MICHAEL;RILEY, ANTHONY LEONARD MARK;STOREY, ANTHONY EAMON |
分类号 |
A61K38/00;A61K51/08;C07K14/655;(IPC1-7):C07K1/13;C07K7/00;C07K14/435 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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