发明名称 |
PEPTIDES AND METHODS AGAINST PSORIASIS |
摘要 |
This invention relates to methods of preventing or reducing the severity of psoriasis. In one embodiment, the method involves administering to the individual a peptide having substantially the sequence of a non-conserved region sequence of a T cell receptor present on the surface of T cells mediating psoriasis or a fragment thereof, wherein the peptide or fragment is capable of causing an effect on the immune system to regulate the T cells. In particular, the T cell receptor has the V beta region V beta 3, V beta 13.1 or V beta 17. In another embodiment, the method involves gene therapy. The invention also relates to methods of diagnosing psoriasis by determining the presence of psoriasis predominant T cell receptors.
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申请公布号 |
WO9519375(A1) |
申请公布日期 |
1995.07.20 |
申请号 |
WO1995US00658 |
申请日期 |
1995.01.13 |
申请人 |
THE IMMUNE RESPONSE CORPORATION |
发明人 |
CHANG, JENNIE, C., C.;BROSTOFF, STEVEN, W.;CARLO, DENNIS, J. |
分类号 |
A61K38/00;A61K31/70;A61K39/00;A61K39/395;A61K48/00;A61P17/00;A61P17/06;A61P37/00;A61P37/02;C07K14/725;C07K16/28;C07K16/42;C12N15/09;C12N15/12;G01N33/569;(IPC1-7):C07K14/725;A61K38/17;G01N33/68 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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