| 摘要 |
<p>The disclosure is of compounds of the formula (I): C6-H5-CH(OH)-CH(R1)-NH-(CH2)m-O-(CH2)n-R2, wherein R1 represents hydrogen or 1-4C-alkyl; R2 represents a phenyl group substituted by R3 and R4, a pyridyl group, phenoxy group, naphthyl group, thienyl group or benzhydryl group, R3 and R4 representing respectively hydrogen, a halogen, hydroxyl (-OH), 1-4C-alkyl, 1-4C-alkoxy, benzyloxy, nitro (-NO2), trifluoromethyl (-CF3), 1-4C-alkoxycarbonyl (-CO-O-1-4C-alkyl), carbamoyl (-CO-NH2), di-1-4C-alkyl carbamoyl [-CO-N(1-4C-alkyl)2], amino (-NH2) or mono- or di-(1-4C-alkyl) amino R4, and hydrogen, a halogen, hydroxyl (-OH), 1-4C-alkyl or 1-4C-alkoxyl, or alternatively, R3 and R4 can together form a methylene dioxy (-O-CH2-O-) or ethylene dioxy (-O-OCH2-CH2-O-) group; m is an integer between 4 and 10, n is an integer between 0 and 7, m being not equal to 4 or 5 if n is 0. The compounds according to the invention possess useful pharmacological properties. They are above all effective β-adreno-receptor agonists (β-sympathomimetics) with predominantly β2-stimulating properties and characterised by good solubility.</p> |
