发明名称 |
Fibrinolytic and anti-thrombotic cleavable dimers |
摘要 |
PCT No. PCT/GB90/01911 Sec. 371 Date Jun. 3, 1992 Sec. 102(e) Date Jun. 3, 1992 PCT Filed Dec. 7, 1990 PCT Pub. No. WO91/09125 PCT Pub. Date Jun. 27, 1991.Relatively inactive fusion proteins are activatable by enzymes of the clotting cascade to have fibrinolytic and/or clot formation inhibition activity. For example, a fusion protein comprising two hirudin or streptokinase molecules, linked by a cleavable linkage sequence, may be cleaved to yield anti-thrombotic hirudin or fibrinolytic streptokinase by thrombin or Factor Xa. Fibrinolytic or clot formation inhibition activity is therefore directed to the site of clot formation. Cleavable streptokinase/hirudin heterodimers are claimed.
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申请公布号 |
US5434073(A) |
申请公布日期 |
1995.07.18 |
申请号 |
US19920854596 |
申请日期 |
1992.06.03 |
申请人 |
BRITISH BIO-TECHNOLOGY LIMITED |
发明人 |
DAWSON, KEITH;HUNTER, MICHAEL G.;CZAPLEWSKI, LLOYD G. |
分类号 |
A61K38/46;A61K38/00;A61K38/48;A61K38/55;A61P7/02;C07K7/64;C07K14/00;C07K14/315;C07K14/745;C07K14/81;C07K14/815;C07K19/00;C12N;C12N1/19;C12N1/21;C12N5/10;C12N9/48;C12N9/64;C12N9/68;C12N9/70;C12N9/72;C12N15/09;C12N15/15;C12N15/57;C12N15/62;C12N15/81;C12N15/85;C12P21/02;(IPC1-7):C12N9/70 |
主分类号 |
A61K38/46 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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