Composition and method of treating depigmentation disorders

摘要

PCT No. PCT/GB92/00878 Sec. 371 Date Nov. 15, 1993 Sec. 102(e) Date Nov. 15, 1993 PCT Filed May 15, 1992 PCT Pub. No. WO92/20354 PCT Pub. Date Nov. 26, 1992.Vitiligo and other tyrosinase-positive depigmentation disorders are treated by topical application of a pseudocatalase and subsequent exposure to a sub-minimal erythema dose of UVB light. After a course of treatment, pigmentation of the affected areas can be maintained by treatment with the pseudocatalases without UVB light treatment. The preferred pseudocatalases are transition metal co-ordination complexes, especially manganese (II) bicarbonate.