NEW CONDENSED CYCLIC COMPOUND OR ITS SALT AND ITS MEDICINAL USE

摘要

PURPOSE:To obtain a low toxic new condensed cyclic compound having excellent glycoprotein GPIIb/III antagonistic activity, capable of oral administration, long in blood life, having low side effects, thus useful for preventing and treating thrombosis etc. CONSTITUTION:This condensed cyclic compound (or a pharmacologically permissible salt thereof) is represented by formula I {A is of formula II, III or IV (E is H, amidino, guanidino or an amino protecting group; (e) is 0-3); B is of formula V, VI, VII or VIII [D is of formula IX (Q is 0 or NR<6>; (g) is O or 1; (h) is 0-3); (m) is 0 or 1; (n) is 1 or 2; (f) is 1-3]; R<1> to R<4> are each H, a lower alkyl, a halogen, an acyl or an alkoxyl; R<5> is H, a lower alkyl, a cycloalkyl or an aralkyl; R<6> is H, a lower alkyl or an aralkyl; G is CH or N; L and M are each O or NR<6>; (a) and (c) are each 0 or 1; (b) and (d) are each 0-3}, e.g. 2-amidino-6-{[(4-methoxycarbonylcyc-lohexyl) aminocarbonyl]methoxy}naphthalene.