| 摘要 |
The invention relates to 9-deoxo-9a-aza-11-deoxy-9a-homoerythromycin A 9a,11-cyclic carbamates, novel semisynthetic macrolide antibiotics from the genus of azalides, of the formula (I) <IMAGE> wherein R1=R2=CO2CH2C6H5, R3=R4=CH3,(IA) R1=R2=CO2CH2C6H5, R3=CH3, R4=H,(IB) R1=R2=CO2CH2C6H5, R3=R4=H,(IC) R1=R2=H, R3=R4=CH3,(ID) R1=R2=R4=H, R3=CH3,(IE) R1=R2=R3=R4=H,(IF) R1=H, R2=R3=R4=CH3,(IG) R1=R4=H, R2=R3=CH3,(IH) R1=R3=R4=H, R2=CH3,(IJ) to pharmaceutically acceptable addition salts thereof with inorganic or organic acids, to intermediates and to processes for the preparation thereof, to a process for preparing pharmaceutical compositions as well as to the use of the obtained pharmaceutical compositions in treatment of bacterial infections.
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