发明名称 Chimeric CTLA4 receptor and methods for its use
摘要 The invention identifies the CTLA4 receptor as a ligand for the B7 antigen. The complete amino acid sequence encoding human CTLA4 receptor gene is provided. Methods are provided for expressing CTLA4 as an immunoglobulin fusion protein, for preparing hybrid CTLA4 fusion proteins, and for using the soluble fusion proteins, fragments and derivatives thereof, including monoclonal antibodies reactive with B7 and CTLA4, to regulate T cell interactions and immune responses mediated by such interactions.
申请公布号 US5434131(A) 申请公布日期 1995.07.18
申请号 US19930067684 申请日期 1993.05.26
申请人 BRISTOL MYERS SQUIBB CO. 发明人 LINSLEY, PETER S.;LEDBETTER, JEFFREY A.;DAMLE, NITIN K.;BRADY, WILLIAM
分类号 A61K38/00;A61K38/17;A61K39/00;A61K39/395;A61K45/00;A61P29/00;A61P31/12;A61P31/14;A61P31/18;A61P35/00;A61P37/00;A61P37/02;A61P37/06;A61P37/08;C07K;C07K14/00;C07K14/705;C07K14/715;C07K14/725;C07K16/00;C07K16/28;C07K16/42;C07K19/00;C12N5/06;C12N5/10;C12N15/02;C12N15/09;C12N15/12;C12N15/13;C12P21/02;C12P21/08;C12R1/91;G01N33/53;G01N33/564;G01N33/566;G01N33/577;(IPC1-7):A61K38/17 主分类号 A61K38/00
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