发明名称 |
INFLUENZA VACCINE |
摘要 |
The present invention relates to a recombinant neuraminidase to be obtained by culturing in a suitable culture medium host cells which are transformed with a neuraminidase expression vector or infected with a virus which is transformed with a neuraminidase expression vector, wherein the expression vector comprises at least a part of the coding region of a neuraminidase gene of an influenza virus minus the region which codes for the membrane anchor, or a modified version thereof, preceded in phase by a signal sequence; and isolating the expression product neuraminidase from the culture medium. The invention further relates to a vaccine in which the recombinant neuraminidase is applied, and methods for manufacturing and purifying thereof. |
申请公布号 |
CA2180965(A1) |
申请公布日期 |
1995.07.13 |
申请号 |
CA19952180965 |
申请日期 |
1995.01.06 |
申请人 |
RIJKSUNIVERSITEIT GENT;FIERS, WALTER CHARLES |
发明人 |
FIERS, WALTER CHARLES;DEROO, TOM MARIA;MIN JOU, WILLY ALFONS |
分类号 |
C12N15/09;A61K38/47;A61K39/00;A61K39/145;A61P31/12;A61P31/16;C07H21/04;C07K14/11;C12N1/19;C12N5/10;C12N9/24;C12N15/56;C12N15/81;C12N15/86;C12R1/84 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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