发明名称 NOVEL OPTIONALLY SUBSTITUTED PHENYLIMIDAZOLIDINES, INTERMEDIATES AND PROCESS FOR THEIR PREPARATION, THEIR USE AS DRUGS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
摘要 Products of general formula (I); wherein Z1 and Z2, which are the same or different, are cyano, nitro, halogen, trifluoromethyl or free, esterified or salified carboxy; the grouping -A-B- is selected from radicals (a) and (b) wherein X is oxygen or sulphur, R3j is R3 except for the hydrogen value, R3 is selected from the following radicals: hydrogen, optionally substituted alkyl, alkenyl, alkynyl, aryl or aryl-alkyl; Y is oxygen or sulphur or NH, R4 and R5, which are the same or different, are chiefly hydroxyl-substituted alkyl, except for products wherein R4 and R5, which are the same or different, are hydrogen or a (C1-C12) alkyl radical optionally substituted by one or more halogen atoms or R4 and R5 are a (C1-C7) cycloalkyl radical or one of R4 or R5 is methyl, the other being hydroxymethyl, Y is oxygen or NH, -A-B- is (c), Z1 is a 4-nitro radical and Z2 a 3-CF3 radical.
申请公布号 WO9518794(A1) 申请公布日期 1995.07.13
申请号 WO1995FR00004 申请日期 1995.01.04
申请人 ROUSSEL UCLAF;CLAUSSNER, ANDRE;GOUBET, FRANCOIS;TEUTSCH, JEAN-GEORGES 发明人 CLAUSSNER, ANDRE;GOUBET, FRANCOIS;TEUTSCH, JEAN-GEORGES
分类号 A61K31/415;A61K31/4166;C07D233/76;C07D233/78;C07D233/84;C07D233/86;C07D233/88;C07D235/02 主分类号 A61K31/415
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