SURROGATES FOR TARGETS AND IMPROVED REFERENCE PANELS

摘要

A method to determine reactivity of a candidate compound with a target which method does not require the physical presence of the target is disclosed. By providing a formula for treating data obtained from a reference set of target substitutes which formula is predictive of reactivity with the target, the compound to be tested can be physically assessed with respect to the reference panels, the formula applied, and reactivity with the actual target may be predicted. Panels which consist of individual members, said members comprising proteins, wherein at least one of the members of the panel is a protein other than an immunoglobulin (Ig) or fragment thereof and wherein the presence of said non-Ig protein enriches the panel are described. These panels can be tested for reactivity with an analyte to create a profile. Such profiles can be used in pattern matching, analysis of samples and other analyses.