POLYMER-SUPPORTED SOLUTION SYNTHESIS OF OLIGOSACCHARIDES

摘要

A method for the synthesis of oligosaccharides on a polymer support that allows to perform glycosylation steps in solution whereas the products are isolated by precipitation with an anhydrous ether and purified by crystallization from an alcohol. The oligosaccharide is attached to the polymer polyethylene glycol monomethyl ether by diether bonds to a dihydroxybenzylic linker. The oligosaccharide is released from the polymer and the linker by hydrogenolysis over catalysts. The method is both rapid and simple. The novel compounds oligosaccharides linked to the polymer via the linker are products with utility in various industries comprising pharmaceutical, biotechnology and food industries.