Signal sequences for secretion of heterologous proteins from yeast.

摘要

The present invention relates to secretion signal peptides of inulinase derived from Kluyveromyces marxianus, which cause a heterologous protein produced in a yeast cell to be secreted almost completely into the extracellular medium; nucleotide sequences encoding said secretion signal sequences; expression and secretion vectors comprising nucleotide sequences encoding said secretion signal peptides; recombinant yeast cells transformed with said expression and secretion vectors; and a process for producing heterologous proteins by culturing said recombinant yeast cells.