Recombinant 3-des-OH-cystatin C produced by expression in a procaryotic host cell

摘要

A recombinant cystatin C polypeptide or a derivative thereof, such as 3-des-hydroxy-cystatin C, is produced biosynthetically by fermentation of a microorganism into which plasmids containing a DNA-sequence coding for said polypeptide have been introduced. Preparations containing recombinant cystatin C, preferably 3-des-hydroxy-cystatin C, have a higher cystein proteinase inhibitor activity than native cystatin C, isolated from human fluids. Such preparations are useful in therapeutic treatments of patients suffering from different diseases, for example herbes simplex.