| 发明名称 |
POLYSACCHARIDE-PROTEIN CONJUGATES |
| 摘要 |
Vi capsular polysaccharides conjugated to toxin-dependent proteins can be used to enhance antibody response and to convert T-dependent properties to the Vi capsular polysaccharide. A heterobifunctional crosslinking agent can be used to bind thiol derivatives of the Vi capsular polysaccharides to the proteins, such as diphtheria, tetanus toxoids, cholera toxin and Haemophilus influenzae.
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| 申请公布号 |
CA1336308(C) |
申请公布日期 |
1995.07.11 |
| 申请号 |
CA19880582233 |
申请日期 |
1988.11.04 |
| 申请人 |
RETARY U.S. DEPARTMENT OF DCOMMERCE (THE) |
发明人 |
SZU, SHOUSUN, C.;SCHNEERSON RACHEL;ROBBINS, JOHN, H. |
| 分类号 |
A61K39/05;A61K39/02;A61K39/08;A61K39/106;A61K39/112;A61K39/145;A61K39/385;A61K39/39;A61K39/395;A61K47/48;C07K17/10;(IPC1-7):C07K17/02 |
主分类号 |
A61K39/05 |
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