| 摘要 |
Compounds of the structure <IMAGE> wherein W is selected from <IMAGE> where Q is oxygen or sulfur, R6 and R7 are hydrogen or alkyl, or R6 and R7, together with the nitrogen atoms to which they are attached, define a radical of formula <IMAGE> R8 is selected from hydrogen, alkyl, haloalkyl, optionally substituted phenyl, hydroxyalkyl, aminoalkyl, carboxyalkyl, (alkoxycarbonyl)alkyl, and (alkylaminocarbonyl)alkyl; Z is -CH2-, oxygen, sulfur, or -NR9 where R9 is hydrogen or alkyl, L1 and L2 are selected from a valence bond, alkylene, propenylene, and propynylene, R1, R2, R3, and R4 are independently selected from alkyl, haloalkyl, halogen, cyano, amino, alkoxycarbonyl, and dialkylaminocarbonyl, Y is selected from oxygen, -NR10, where R10 is hydrogen or alkyl, and <IMAGE> where n=0, 1, or 2, and R5 is alkyl, inhibit the biosynthesis of leukotrienes. These compounds are useful in the treatment or amelioration of allergic and inflammatory disease states.
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