发明名称 Homologous recombination antibody expression system for murine cells
摘要 A specific locus in the genome of a murine host cell is identified which causes high levels of recombinant gene expression following stable integration, via homologous recombination, of the recombinant gene into the specific chromosomal locus. The selection of a favorable genome locus for the insertion and expression of a recombinant gene is disclosed, as are DNA vectors and host cells.
申请公布号 AU1278695(A) 申请公布日期 1995.07.10
申请号 AU19950012786 申请日期 1994.12.22
申请人 MERCK & CO., INC. 发明人 GREGORY FRANKLIN HOLLIS;GEORGE E. MARK
分类号 C12N15/09;C07K16/00;C12N5/10;C12N15/85;C12N15/90;C12P21/02 主分类号 C12N15/09
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