HUMANIZED ANTIBODIES AND USES THEREOF

摘要

PCT No. PCT/IB94/00387 Sec. 371 Date Jun. 6, 1996 Sec. 102(e) Date Jun. 6, 1996 PCT Filed Nov. 21, 1994 PCT Pub. No. WO95/16038 PCT Pub. Date Jun. 15, 1995The present invention relates to humanized antibodies and binding proteins thereof, capable of binding to T cells exhibiting particular variable beta chains, and particularly those subpopulations expressing human V beta 5.2 and/or 5.3, and V beta 8.1. The present invention also relates to the preparation of such antibodies, to pharmaceutical compositions containing them, and therapeutic utilization of the antibodies, specifically in autoimmune diseases.