发明名称 |
RECOMBINANT ADENOVIRAL VECTOR AND METHODS OF USE |
摘要 |
This invention provides a recombinant adenovirus expression vector characterized by the partial or total deletion of the adenoviral protein IX DNA and having a gene encoding a foreign protein or a functional fragment or mutant thereof. Transformed host cells and a method of producing recombinant proteins and gene therapy are also included within the scope of this invention. Thus, for example, the adenoviral vector of this invention can contain a foreign gene for the expresssion of a protein effective in regulating the cell cycle, such as p53, Rb, or mitosin, or in inducing cell death, such as the conditional suicide gene thymidine kinase. |
申请公布号 |
WO9511984(A3) |
申请公布日期 |
1995.07.06 |
申请号 |
WO1994US12235 |
申请日期 |
1994.10.25 |
申请人 |
CANJI, INC. |
发明人 |
GREGORY, RICHARD, J.;WILLS, KEN, N.;MANEVAL, DANIEL, C. |
分类号 |
C12N15/09;A61K31/70;A61K35/76;A61K38/00;A61K48/00;A61P35/00;C07H21/04;C07K14/47;C12N5/10;C12N7/00;C12N15/861 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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