THIENODIAZEPINE COMPOUND AND MEDICINAL USE THEREOF.

摘要

A thienodiazepine compound represented by general formula (I), a salt thereof, and a medicinal use thereof, wherein R<3> represents a group represented by any of the following formulae: (1), -(CH2)aN(R<4>)COR<7> (2), -(CH2)aN(R<8>)SO2R<9> (3), -(CH2)aN(R<8>)COOR<1><0> (4), -(CH2)aOCON(R<1><1>)(R<1><2>) (5), -(CH2)aCON(R<1><3>(R<1><4>) (6), -(CH2)aOCOR<1><5> (7), -(CH2)aOSO2R<1><6> (8), -(CH2)aCOR<1><7> (9) and -(CH2aS(O)nR<1><8> (10), a represents an integer of 0, 1 to 6 ; Z represents oxygen or sulfur ; and X represents oxygen or sulfur, provided that X and Y may be combined together to represent = N-N = C(R<2><0>)- or = N-CH = C(R<2><0>)-. This compound has CCK antagonism, gastrin antagonism and cell fusion inhibitor activity, thus being useful as a medicine. <CHEM>