Novel quinazoline derivatives and a process for the preparation thereof

摘要

Compounds of the general formula (wherein R1 represents a halogen atom or a trifluoromethyl, nitro, cyano, C1- 7 alkyl, C1- 7 alkoxy or C1- 7 alkylthio group, R2 represents a halogen atom, R3 represents a C1- 7 alkyl or halo-(C1- 7 alkyl) group, R4 represents a C1- 6 alkyl group and the broken lines denote optional substituents) and their acid addition salts are prepared by reacting a compound of the formula (wherein X represents a halogen atom) under anhydrous conditions at a temperature of from -40 DEG to + 40 DEG C. with not substantially more than 1 mol. of a non-nucleophilic strong base for each mol. of the quinazoline derivative. optionally followed by salt formation. The haloalkyl groups contain one or more halogen atoms.