Fremgangsmåte for fremstilling av E-1-[4'-(2-dimetyl-aminoetoksy)-fenylÅ-1-(3'-hydroksyfenyl)-2-fenyl-1-buten

摘要

PCT No. PCT/EP94/00001 Sec. 371 Date Sep. 23, 1996 Sec. 102(e) Date Sep. 23, 1996 PCT Filed Jan. 3, 1994 PCT Pub. No. WO95/18786 PCT Pub. Date Jul. 13, 1995The present invention relates to methods for the production of E-1-[4'-(2-dimethylaminoethoxy)-phenyl]-1-(3'-hydroxyphenyl)-2-phenyl-1-butene of formula (I) which comprises heating the compound of formula (II) in the presence of an organic solvent and HCl gas and cooling the reaction to obtain the compound of formula (IIIa), and then heating the isolated compound of formula (IIIa) in the presence of sulfuric acid or hydrochloric acid to obtain the compound according to formula (I). Formula (I) Formula (II) e protecting group