2'-alkylidenepyrimidine nucleoside derivatives, process for production thereof, and uses thereof

摘要

Disclosed are novel 2'-alkylidenepyrimidine nucleoside derivatives represented by formula [I]: <IMAGE> [I] R1 is an amino group or a hydroxy group, R2 is a hydrogen atom, a halogen atom or a lower alkyl group, R3 is a hydrogen atom or a lower alkyl group, and R4 is a hydrogen atom or a phosphate residue, or salts thereof. These novel compounds can be produced from uridine or cytidine derivatives by alkylidenating the 2'-position in the sugar moiety thereof with Wittig's reagent. Furthermore, the compounds have remarkable antiviral activities and therefore can provide novel antiviral agents.