| 摘要 |
Synthetic peptides which consist of 5 to 25 amino acids including an amino acid sequence comprising at least IGF-1 amino acids 60-64 wherein amino acid 60 is substituted or derivatized are disclosed. The peptides inhibit IGF-1 induction of autophosphorylation by IGF-1R. Pharmaceutical compositions comprising the peptides together with pharmaceutically acceptable carriers or diluents are disclosed. Methods of inhibiting proliferation of cells that comprise human insulin-like growth factor 1 receptors comprising contacting a proliferating cell and methods of treating an individual suspected of suffering from or susceptible to a disease associated with undesirable cell proliferation are disclosed. |
