PEPTIDE ANALOGS OF THE FACTOR IXa PLATELET BINDING SITE

摘要

Synthetic peptide analogs of human factor IXa are provided which are conformationally restricted by means of intramolecular bonding. The peptides compete with native factor IXa for binding to a platelet surface, and thereby inhibit the factor IXa-induced activation of factor X on the surface of platelet. The peptides are designed by means of an equilibrium conformational model of the factor IXa Gla domain.