PLATELET GPIIIa P1?A1 AND P1?A2 EPITOPES, THEIR PREPARATION AND USE.

摘要

Polypeptides and fusion polypeptides that immunologically mimic the native PlA1 and PlA2 determinants of platelet protein GPIIIa are disclosed. Also disclosed are DNA segments and recombinant DNA molecules that encode those polypeptides and fusion polypeptides and methods for expressing and using those determinants. Antibodies that immunoreact with one determinant or the other, but not both are also disclosed, as are methods of preparing and using those antibodies.