摘要 |
Compounds of the formula: <IMG> I wherein R1 and R2 are independently selected from hydrogen, C1 to C4 alkyl, or hydroxy, but R1 and R2 are not simultaneously hydroxy; wherein X is selected from (C(R4)2)m, where m=1 to 3; wherein R4 is selected independently at each occurrence from hydrogen, or C1 to C4 alkyl, wherein R3 is <IMG> or <IMG> or <IMG> wherein Y1 is selected from (1) hydrogen, (2) C1 to C6 alkyl, (3) C2 to C6 alkenyl, (4) C1 to C6 alkoxy, (5) C3 to C8 cycloalkyl, (6) aryl, (7) aryloxy, (8) aroyl, (9) C1 to C6 arylalkyl, (10) C2 to C6 arylalkenyl, (11) C1 to C6 arylalkoxy, (12) C1 to C6 arylthioalkoxy, or substituted derivatives of (13) aryl, (14) aryloxy, (15) aroyl, (16) C1 to C6 arylalkyl, (17) C2 to C6 arylalkenyl, (18) C1 to C6 arylalkoxy, (19) C1 to C6arylthioalkoxy, wherein substituents are selected from halo, nitro, cyano, C1 to C6 alkyl, alkoxy, or halosubstituted alkyl; wherein Y2 is selected from hydrogen, halogen, hydroxy, cyano, halosubstituted alkyl, or Y1; and finally wherein M is hydrogen, a pharmaceutically acceptable cation, aroyl, or C1 to C6 alkoyl are potent inhibitors of the enzyme 5-lipoxygenase.
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