Certain 4-aryl substituted piperazinyl and piperidinylmethyl phenylimidazole derivatives; a new class of dopamine receptor subtype specific ligands

摘要

PCT No. PCT/US91/09816 Sec. 371 Date Nov. 8, 1993 Sec. 102(e) Date Nov. 8, 1993 PCT Filed Dec. 23, 1991.This invention encompasses compounds of the formulas: <IMAGE> where R1, R3, R4, R6, X, Y, and Z are T are variables; and M is <IMAGE> or gether may represent -(CH2)n1 where n1 is 1, 2, or 3. These compounds are highly selective partial agonists or antagonists at brain dopamine receptor subtypes or prodrugs thereof and are useful in the diagnosis and treatment of affective disorders such as schizophrenia and depression as well as certain movement disorders such as Parkinsonism. Furthermore compounds of this invention may be useful in treating the extraparamidyl side effects associated with the use of conventional neuroleptic agents.