发明名称 |
1-(3'-SUBSTITUED-2', 3'-DIDEOXY-D-RIBOFURANOSYL) THYMINE AND URACIL |
摘要 |
A compound of the formula <IMG> wherein the radicals A, X, R1, R2, and R3 are defined as follows: A : (a) <IMG> or (b) <IMG> X : (a) O (b) S (c) CH2 R1: H; alkyl containing 1-3 carbon atoms; -CH=CH2; -CH=CH-CH3; -CH2-CH=CH2; <IMG> ; -C?CH R2: H; or R2 constitutes together with R3 a carbon - carbon bond R3: H; F; Cl; Br; I; N3; CN; C?CH; OH; OCH3; CH2OH; and when R3 is F; Cl, Br; I; N3 ; CN; C?CH; OH; OCH3 or CH2OH it may have either the cis-configuration or trans-configuration relative to the hydroxymetyl function at position 4', or R3 constitutes together with R2 a carbon carbon bond, and therapeutically acceptable salts thereof, for use in therapy, in particular for the treatment of HIV virus infections.
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申请公布号 |
CA1336088(C) |
申请公布日期 |
1995.06.27 |
申请号 |
CA19880580141 |
申请日期 |
1988.10.14 |
申请人 |
MEDIVIR AB |
发明人 |
DATEMAN, ROELF;KOVACS, ZSUZSANNA M. I.;JOHANSSON, KARL N. G.;LINDBORG, BJOERN G.;STENING, GOERAN B.;BERG, BO F. |
分类号 |
C07D239/47;A61K31/505;A61K31/70;A61K31/7042;A61K31/7052;A61K31/7064;A61K31/7068;A61K31/7072;A61P31/12;C07D239/54;C07H19/06;(IPC1-7):C07D239/54;C07H19/073 |
主分类号 |
C07D239/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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