3-SUBSTITUTED 1-ARYLINDOLE COMPOUNDS

摘要

3-Substituted 1-arylindole compound having general formula (I) wherein Ar is an optionally substituted aryl group; X represents a bond, a divalent hydrocarbon group or methyleneoxy or -thioxo; R<1>-R<2> are hydrogen or substituents; R<5> is hydrogen, hydroxy, alkoxy, halogen, trifluoromethyl, alkyl or alkenyl; R<6> and R<7> are hydrogen, alkyl or alkenyl; R<8> is alkyl or alkenyl or represents a group of formula (1a) or (1b); wherein: W is O or S; U is N or CH; Z is (CH2)m, 1,2-phenylene, CH=CH, COCH2 or CSCH2-; V is O, S, CH2, or NR<10>, wherein R<10> is hydrogen or alkyl; U<1> is O, S, CH2 or NR<11>, wherein R<11> is as R<10>; and V<1> is NR<12>R<13>, OR<14>, SR<15> or CR<16>R<17>R<18>, where each of R<12>-R<18> are as the R<10>-substituents; R<9> is hydrogen or alkyl; or R<9> is linked to R<7> to form a ring; or R<8> and R<9> together form a morpholinyl or piperidinyl ring, the latter optionally substitued by alkyl or a group of formula (1a) or (1b), or a carbamoyl group, show central antiserotonergic activity and possibly also antidopaminergic activity and are, accordingly, useful in the treatment of central nervous system (CNS) disorders. The compounds are prepared by methods known per se.